Product Name :
Rad21 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CDLS4 antibody Double-strand-break repair protein rad21 homolog antibody hHR21 antibody HR21 antibody HRAD21 antibody KIAA0078 antibody MCD1 antibody Nuclear matrix protein 1 antibody NXP-1 antibody NXP1 antibody 展开
Function :
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within Human Rad21 aa 252-456 / 631.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3069268
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol.(S)-3-Fluoropyrrolidine (hydrochloride) structure Preservative: 0.Methyl 3-fluoroisonicotinate site 05% Sodium Azide.PMID:33723488
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 72 kDa
Positive control :
Mouse ovary tissue lysate, Daudi cell lysate, MG-63, SiHa, SK-Br-3, rat brain tissue, human thyroid gland carcinoma tissue, human colon tissue, mouse testis tissue.