Product Name :
TOK-1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
bccip antibody BCCIP_HUMAN antibody BCCIPalpha antibody BCCIPbeta antibody BRCA2 and CDKN1A interacting protein antibody BRCA2 and CDKN1A-interacting protein antibody BRCA2 and Cip1/p21 interacting protein antibody Cdk inhibitor p21 binding protein antibody P21 and CDK associated protein 1 antibody P21- and CDK-associated protein 1 antibody 展开
Function :
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthesized peptide derived from TOK-1 .309964-23-6 Order at AA range: 60-140
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.288617-75-4 site Aliquot store at -20℃ or -80℃.PMID:33586542 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
35 kDa
Positive control :
Brain,Epithelium,