Product Name :
Tyk2 Rabbit Polyclonal Antibody
Predicted band size :
134 kDa
Observed band size :
134 kDa
Synonyms:
JTK 1 antibody JTK1 antibody Non receptor tyrosine protein kinase 2 antibody Non receptor tyrosine protein kinase TYK2 antibody Non-receptor tyrosine-protein kinase TYK2 antibody OTTHUMP00000232745 antibody OTTHUMP00000232746 antibody OTTHUMP00000232748 antibody Protein Tyrosine Kinase 2 antibody TYK 2 antibody 展开
Function :
TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.37700-64-4 Formula
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within human TYK2 aa 390-620.Formula of 8-Bromo-1,6-naphthyridine
Species reactivity:
Human, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069204
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33390056 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 134 kDa
Positive control :
Raji cell lysate, Jurkat cell lysate, A549 cell lysate, MCF-7, human liver carcinoma tissue, human colon tissue, rat kidney tissue.