Product Name :
24-Hydroxycholesterol (CAS 30271-38-6)
Synonym :
Cholest-5-ene-3β,24-diol; (3β)-Cholest-5-ene-3,24-diol
Application :
24-Hydroxycholesterol is 24-Hydroxycholesterol a main cholesterol elimination product of the brain
CAS:
30271-38-6
Purity:
Molecular Weight:
402.65
Formula :
C27H46O2
Physical state:
Solid
solubility :
Shipping Condition :
Store at 4° C
Melting point:
SMILES:
References:
:Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | Li-Hawkins, J., et al. 2000. J Biol Chem. 275: 16543-9. PMID: 1074804724-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | Norlin, M., et al. 2000. J Lipid Res. 41: 1629-39. PMID: 11013305Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. | Kölsch, H., et al. 2001. J Neural Transm (Vienna). 108: 475-88. PMID: 11475014Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | Prasanthi, JR., et al. 2009. Mol Neurodegener. 4: 1. PMID: 19126211Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. | Fourgeux, C., et al. 2009. Invest Ophthalmol Vis Sci. 50: 5712-7. PMID: 1955361224-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. | Cook, IT., et al. 2009. Drug Metab Dispos. 37: 2069-78. PMID: 19589875Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid- beta in amplifying neuronal damage in Alzheimer′s disease: three partners in crime. | Gamba, P., et al. 2011. Aging Cell.1,3,5-Tri(pyridin-4-yl)benzene web 10: 403-17.Formula of 3-(4-Bromophenyl)oxetan-3-ol PMID: 21272192Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification? | La Marca, V.PMID:33400886 , et al. 2016. Neurosci Res. 105: 19-27. PMID: 26454063Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer′s Disease: A Meta-Analysis. | Wang, HL., et al. 2016. J Alzheimers Dis. 51: 45-55. PMID: 26836015Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders. | Grayaa, S., et al. 2018. Biochimie. 153: 80-85. PMID: 29730299A silver lining for 24-hydroxycholesterol in Alzheimer′s disease: The involvement of the neuroprotective enzyme sirtuin 1. | Testa, G., et al. 2018. Redox Biol. 17: 423-431. PMID: 29883958Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | Zhang, J., et al. 1997. Biochem J. 322 (Pt 1): 175-84. PMID: 9078259The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. | Kölsch, H., et al. 1999. Brain Res. 818: 171-5. PMID: 9914453