Product Name :
2′-O-Methyladenosine (CAS 2140-79-6)
Synonym :
Application :
2′-O-Methyladenosine is an analog of adenosine
CAS:
2140-79-6
Purity:
≥98%
Molecular Weight:
281.27
Formula :
C11H15N5O4
Physical state:
Solid
solubility :
Soluble in DMSO, methanol, and DMF.
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3N)CO)O
References:
:THE DIRECT PREPARATION OF 2′-O-METHYLADENOSINE FROM ADENOSINE. | BROOM, AD. and ROBINS, RK. 1965. J Am Chem Soc. 87: 1145-6. PMID: 142846322′-O methylation of internal adenosine by flavivirus NS5 methyltransferase. | Dong, H., et al. 2012. PLoS Pathog. 8: e1002642. PMID: 22496660The 2′-O-methyladenosine nucleoside modification gene OsTRM13 positively regulates salt stress tolerance in rice. | Wang, Y., et al. 2017. J Exp Bot. 68: 1479-1491. PMID: 28369540Structural and Energetic Effects of O2′-Ribose Methylation of Protonated Purine Nucleosides. | He, CC., et al. 2018. J Phys Chem B. 122: 9147-9160. PMID: 30203656FTSJ1 regulates tRNA 2′-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression. | He, Q., et al. 2020. Cell Death Dis. 11: 348. PMID: 32393790A comprehensive review of m6A/m6Am RNA methyltransferase structures. | Oerum, S., et al. 2021. Nucleic Acids Res. 49: 7239-7255. PMID: 34023900Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer. | Fang, Z., et al. 2021. Front Mol Biosci. 8: 741603. PMID: 34513933HILIC-MS/MS for the Determination of Methylated Adenine Nucleosides in Human Urine. | Guo, C., et al. 2021. Anal Chem. 93: 17060-17068. PMID: 34902250RNA 2′-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response. | Li, P., et al. 2022. Front Immunol. 13: 793582. PMID: 35464456Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer.1021-25-6 Data Sheet | Qu, X.2-Methyl-4-(trifluoromethyl)aniline web , et al.PMID:33645490 2022. Cancers (Basel). 14: PMID: 35804965Determination of adenosine and its modifications in urine and plasma from breast cancer patients by hydrophilic interaction liquid chromatography-tandem mass spectrometry. | Zhang, X., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1209: 123428. PMID: 36041348Simultaneous Determination of Methylated Nucleosides by HILIC-MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients. | Fang, Z., et al. 2022. Metabolites. 12: PMID: 36295875A simple method of the preparation of 2′-O-methyladenosine. Methylation of adenosine with methyl iodide in anhydrous alkaline medium. | Yano, J., et al. 1980. Biochim Biophys Acta. 629: 178-83. PMID: 7370305